Hematological changes in adult patients on valproic acid therapy
نویسندگان
چکیده
منابع مشابه
Relationship between Patient Demographic Characteristics, Valproic Acid Dosage and Clearance in Adult Iranian Patients
Objective(s) As there are conflicting findings regarding the clearance-dose and patient characteristics relationships for valproic acid (VPA), this study was conducted to investigate the relationship between patient demographic characteristics, VPA dosage and the drug clearance in adult Iranian patients. Materials and Methods Patients (N= 47) were either on monotherapy with VPA or were under co...
متن کاملFive doubly unsaturated metabolites of valproic acid in urine and plasma of patients on valproic acid therapy.
The urine and plasma of epileptic patients receiving therapeutic doses of valproic acid (2-propyl- pentanoic acid) was found to contain five doubly unsaturated metabolites of valproic acid, which were identified as their trimethylsilyl derivatives by GC/MS. A series of reference substances was synthesized but only two of them were identical with native metabolites: 2(2-propenyl)-4-pentenoic aci...
متن کاملValproic acid-induced pancreatitis in an adult.
Ribeirão Preto School of Medicine, University of São Paulo, São Paulo SP, Brazil: Physician Resident in Neurology, Department of Neurosciences and Behaviour Sciences; Neurologist and Associated Professor, Department of Neurosciences and Behaviour Sciences; Emergencist Physician, Departament of Internal Medicine. Idiosyncratic reactions to drugs are adverse effects not straightly related with ph...
متن کاملrelationship between patient demographic characteristics, valproic acid dosage and clearance in adult iranian patients
objective(s) as there are conflicting findings regarding the clearance-dose and patient characteristics relationships for valproic acid (vpa), this study was conducted to investigate the relationship between patient demographic characteristics, vpa dosage and the drug clearance in adult iranian patients. materials and methods patients (n= 47) were either on monotherapy with vpa or were under co...
متن کاملValproic acid overdose and L-carnitine therapy.
A healthy, nonepileptic 16-month-old child ingested a massive overdose (approximately 4000 mg) of valproic acid (VPA). Upon admission to the hospital, he was in a deep coma and had generalized hypotonicity and no response to pain. His serum and urinary concentrations of VPA were 1316.2 and 3289.5 micrograms/mL, respectively. Urinary concentrations of the beta-oxidation metabolites of VPA were l...
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ژورنال
عنوان ژورنال: International Journal of Clinical and Diagnostic Pathology
سال: 2019
ISSN: 2617-7226,2617-7234
DOI: 10.33545/pathol.2019.v2.i2b.79